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Recombinant Human GDF-15/MIC-1 (H6D)

GDF-15/MIC-1 Applications

Description :

GDF-15/MIC-1 (MIC-1/ GDF-15) belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15/MIC-1 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15/MIC-1 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15/MIC-1 in gestation and embryonic development. GDF-15/MIC-1 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of MIC-1/ GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.

Please note : This is the H6D variant (histidine to aspartic acid at position 6).
 This variant might play a role in prostate cancer.  Availability of the recombinant product may provide new tool to elucidate the role of GDF-15/MIC-1 in prostate cancer and other cancers. For more information please see Applications.

Catalog #:

002-GDF15 (MIC-1) H6D

Source:

HEK 293 cells

Stability:

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -200C. Reconstituted GDF-15/MIC-1 should be stored in working aliquots at -200C.

Purity:

Greater than 98% by SDS-PAGE and HPLC analyses.

Endotoxin Level:

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity:

Testing in progress. 

Country of Origin:

USA



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