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Recombinant Murine Interleukin-12 (p80)

Description :

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant murine IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Catalog #:

001-MIL12P80

Source :

CHO cells (Chinese Hamster Ovarian Cells)

Formulation :

Sterile filtered and then the protein was lyophilized in 1 x PBS pH 6.8.

Stability :

The lyophilized protein, is stable for a few weeks at room temperature, but best stored at -200C. Reconstituted murine IL-12 should be stored in working aliquots at -200C.

Purity :

Greater than 98% by SDS-PAGE and HPLC analyses.

Reconstitution :

We recommend a quick spin followed by reconstitution in 200 ul of sterile water for injection for 0.5 mg/ml concentration . This solution can then be diluted into other aqueous buffers and stored at 40C for 3 months or below -100C for future use.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity :

Not Available.

AA Sequence :

p40 Monomer: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS

PubMed  Link :

IL-12 P80 Mouse

Usage:

For research only. Not for use in diagnostic or therapeutic procedures.

Country of Origin :

USA



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