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Recombinant Human BMP-7 / OP-1

BMP-7 Applications

Description :

TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1™ implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a 30 kDa homodimeric glycoprotein consisting of two 139 amino acid subunits, which correspond to amino acid residues 293 to 431 of the full-length BMP-7 precursor

Catalog #:

001-HBMP7

Source:

CHO cells (Chinese Hamster Ovarian cells)

Stability:

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -200C. Reconstituted BMP-7/OP-1 should be stored in working aliquots at -200C.

Purity:

Greater than 98% by SDS-PAGE and HPLC analyses.

Endotoxin Level:

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity:

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 20-40 ng/ml.

AA Sequence  :

STGSKQRSQ NRSKTPKNQE ALRMANVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPETV PKPCCAPTQL NAISVLYFDD SSNVILKKYR NMVVRACGCH

PubMed  Link :

BMP-7

Country of Origin:

USA



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