Description : |
IGFBPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGFBP-2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGFBP-2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGFBP-2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGFBP domain and thyroglobulin type-I domain. |
Catalog #: |
003-IGFBP2 |
Source: |
High-5 (BTI-Tn-5B1-4) Insect Cells |
Stability: |
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -200C.
Reconstituted h-IGFBP-2 should be stored in working aliquots at -200C. |
Purity: |
Greater than 98% by SDS-PAGE and HPLC analyses. |
Endotoxin Level: |
Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
Biological Activity: |
Determined by its ability to inhibit IGF-I or IGF-II induced proliferation of FDC-P1 cells. |
AA Sequence: |
EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ |
PubMed Link : |
IGFBP-2 |
Usage: |
For research Purposes Only - Made using
a cell BTI-Tn-5B1-4 under license from the Boyce Thompson
Institute for Plant Research, Inc. Not for use in diagnostic
or therapeutic procedures.
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Country of Origin: |
USA
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