---
title: Human IGFBP-4 Recombinant Protein
description: Activin-A is a TGF-beta family member involved in the regulation of cellular proliferation and differentiation, and promotion of neuronal survival.
image: https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2020%2c%202026%2c%2001_19_04%20PM%20(1).png
---

<https://sbhsciences.com/blog/human-igfbp-4-recombinant-protein#body>

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![Human IGFBP-4 Recombinant Protein](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2020%2c%202026%2c%2001_19_04%20PM%20(1).png)

# *[cancer](https://sbhsciences.com/blog/tag/cancer) | [metabolic](https://sbhsciences.com/blog/tag/metabolic) | [neurological](https://sbhsciences.com/blog/tag/neurological) | [cardiovascular](https://sbhsciences.com/blog/tag/cardiovascular)* Human IGFBP-4 Recombinant Protein

Catalog #003-IGFBP4

###### Description

 

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF independent pathway. The biological effects of IGF-BP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGF-BP4/IGF binding affinity by proteolytically cleaving IGF-BP4. The modulation of IGF-BP4 activity by PAPP-A is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells. Recombinant human IGF-BP4 is a 25.8 kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

 

###### Product Specific Information

 

Storage: Reconstituted h-IGFBP-4 should be stored in working aliquots at -200C.

For research Purposes Only. Not for use in diagnostic or therapeutic procedures. 

 

 

 

| PROPERTIES |  |
| --- | --- |
| Species | Human |
| Expression System | High-5, Insect Cells |
| Molecular Weight | 25.8 kDa |
| Full Length | 237 amino acids |
| Purity | ≥98% by SDS-PAGE and HPLC Analyses |
| Form | Lyophilized |
| Endotoxin | \<1 EU/µg |
| Activity | Determined by its ability to inhibit IGF-I or IGF-II induced proliferation of FDC-P1 cells |
| Storage | -20°C |

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