IL-23 is a proinflammatory heterodimeric protein composed of two subunits, a unique p19 subunit and a p40 subunit, which is shared with IL-12.IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ2. IL- 23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFNgamma in NK cells, induces IL-17 production, and drives Th17 mediated responses. Recombinant IL-23 is a 53.5 kDa heterodimeric protein consisting of two subunits, p19 (170 amino acids) and p40 (306 amino acids).
Reconstitution: We recommend a quick spin followed by reconstitution in 1x PBS pH 7.2-7.4 to a concentration of 0.1 mg/ml.
Storage: This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or at -20°C for future use.