---
title: Human IL-6 Receptor (Soluble) Recombinant Protein
description: Activin-A is a TGF-beta family member involved in the regulation of cellular proliferation and differentiation, and promotion of neuronal survival.
---

<https://sbhsciences.com/blog/human-il-6-receptor-soluble-recombinant-protein#body>

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![Human IL-6 Receptor (Soluble) Recombinant Protein](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2020%2c%202026%2c%2012_11_46%20PM.png)

# *[metabolic](https://sbhsciences.com/blog/tag/metabolic) | [kidney](https://sbhsciences.com/blog/tag/kidney) | [neurological](https://sbhsciences.com/blog/tag/neurological) | [immune/inflammation](https://sbhsciences.com/blog/tag/immune-inflammation) | [cardiovascular](https://sbhsciences.com/blog/tag/cardiovascular) | [muscle](https://sbhsciences.com/blog/tag/muscle) | [infection](https://sbhsciences.com/blog/tag/infection)* Human IL-6 Receptor (Soluble) Recombinant Protein

Catalog #002-SIL6R

 

 

###### Description

 

The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component specific to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low affinity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. SBH Sciences’ recombinant human sIL-6R alpha is a 37.6 kDa protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).

 

###### Product Specific Information

 

Reconstitution: We recommend a quick spin followed by reconstitution in 1 x PBS, pH 7.2 to a concentration of 0.1-1.0 mg/ml. 

Storage: This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or stored at -20°C for futures use..

For research Purposes Only. Not for use in diagnostic or therapeutic procedures. 

 

 

| PROPERTIES |  |
| --- | --- |
| Species | Human |
| Expression System | Human Embryonic Stem Cells, HEK-293 |
| Molecular Weight | 37.6 kDa |
| Full Length | 338 amino acids |
| Purity | ≥98% by SDS-PAGE and HPLC Analyses |
| Form | Lyophilized |
| Endotoxin | \<1 EU/µg |
| Activity | The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is \< 10.0 ng/ml, in the presence of 20 ng/ml of rhIL-6 |
| Storage | -20°C |

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