--- title: KIDNEY description: translational kidney disease research platform, functional assays, renal biomarkers, cell disease models for chronic kidney diseases, IgA, kidney injury image: https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2019%2c%202026%2c%2010_57_16%20AM.png --- [![SBH Sciences](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/sbhlogo.png?width=155&height=74&name=sbhlogo.png "SBH Sciences")](https://sbhsciences.com/) - Open submenu for ABOUT US - [ABOUT SBH](https://sbhsciences.com/about-sbh) - [LEADERSHIP](https://sbhsciences.com/sbh-leadership) - [CONTACT](https://sbhsciences.com/contact) - [CAREERS](https://sbhsciences.com/careers) - [SBH BIOVENTURE](https://sbhsciences.com/sbh-bioventure) - [SOLUTIONS](https://sbhsciences.com/services) Show submenu for SOLUTIONS - [CELL BASED ASSAYS](https://sbhsciences.com/cell-based-assay-services) - Open submenu for PRODUCT SERVICES - [PROTEINS](https://sbhsciences.com/protein-production-services) - [MOLECULAR BIOLOGY](https://sbhsciences.com/molecular-biology-services) - 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[CELL CULTURE](https://sbhsciences.com/cell-culture-services) - [ORGANOIDS](https://sbhsciences.com/blog/organoids-mini-organs-grown-for-research-and-drug-development) - [EXOSOMES](https://sbhsciences.com/exosome-services) - [BIOMARKER TESTING](https://sbhsciences.com/biomarker-testing) - Open submenu for DRUG DISCOVERY - [ADCC](https://sbhsciences.com/antibody-development-1) - [ELISA](https://sbhsciences.com/elisa-assays) - [BIOANALYTICAL](https://sbhsciences.com/bioanalytical-discovery-services) - [BIOSIMILARS](https://sbhsciences.com/biosimilars) - [CELL & GENE THERAPY](https://sbhsciences.com/cgt) - [SMALL MOLECULE](https://sbhsciences.com/small-molecule) - [FTE MODEL](https://sbhsciences.com/fte-model) - [CONSULTING](https://sbhsciences.com/mentoring) - Open submenu for INDICATIONS - [NEUROLOGY](https://sbhsciences.com/neurology) - [METABOLIC](https://sbhsciences.com/metabolic) - [ONCOLOGY](https://sbhsciences.com/oncology) - [KIDNEY](https://sbhsciences.com/kidney) - [MUSCLE](https://sbhsciences.com/muscle) - Open submenu for PRODUCTS - [CYTOKINES](https://sbhsciences.com/cytokines) - [MONOCLONAL ANTIBODIES](https://sbhsciences.com/monoclonal-antibodies) - [GLYCOBIOLOGY](https://sbhsciences.com/glycobiology) - Open submenu for INSIGHTS - [NEWS AND BLOG](https://sbhsciences.com/sbh-blog-and-news) - [REFERENCES AND PUBLICATIONS](https://sbhsciences.com/references) - [STRATEGIC PARTNERSHIPS](https://sbhsciences.com/partnerships) Search Search Search Search ![ChatGPT Image Jan 19, 2026, 10\_57\_16 AM](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2019%2c%202026%2c%2010_57_16%20AM.png) # Our Translational Research Platform for Kidney Disease [Talk to an Expert](mailto:mstewart@sbhsciences.com) ## *SBH SCIENCES*Kidney Disease Research Center *We partner with industry and academic institutions to support drug development across a broad range of kidney disease indications by providing comprehensive disease modeling* s*tate-of-the-art functional assays,* *and biomarker discovery and development* *services.*   ## Our In-Vitro Models, Biomarker Platforms, and Functional Assays We have developed a platform of functional assays in a growing range of in vitro models to support drug development programs for key indications in renal disease drug development including: - Diabetic Kidney Disease (DKD) - IgA Nephropathy (IgAN) - Focal Segmental Glomerulosclerosis (FSGS) - Lupus Nephritis (LN) - Autosomal Dominant Polycystic Kidney Disease (ADPKD)   [Download our kidney guide](https://sbhsciences.com/hubfs/SBH%20Kidney%20Disease%20Platform.pdf) ![ChatGPT Image Jan 19, 2026, 11\_06\_04 AM-2](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Jan%2019%2c%202026%2c%2011_06_04%20AM-2.png?width=901&height=999&name=ChatGPT%20Image%20Jan%2019%2c%202026%2c%2011_06_04%20AM-2.png "ChatGPT Image Jan 19, 2026, 11_06_04 AM-2") ![ChatGPT Image Jan 19, 2026, 12\_05\_01 PM-3-1](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2019%2c%202026%2c%2012_05_01%20PM-3-1.png) ### Conditionally Immortalized Human Podocytes - Cytoskeletal architecture and foot process analysis​ - Podocyte survival and detachment​ - Podocyte mitochondrial function and metabolic stress​ - Slit diaphragm integrity​ - Human podocytes disease-specific readout panel ![ChatGPT Image Jan 19, 2026, 12\_05\_01 PM-2-1](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2019%2c%202026%2c%2012_05_01%20PM-2-1.png) ### Primary Human Proximal Tubule Epithelial Cells (hPTECs) - Tubule injury and cytotoxicity​ - Mitochondrial respiration and metabolism​ - Fibrosis - TGF-β–driven fibrotic response​ - Oxidative stress and Autophagy​ - Tubular cell morphology ![ChatGPT Image Jan 19, 2026, 12\_05\_01 PM-1-1-1](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2019%2c%202026%2c%2012_05_01%20PM-1-1-1.png) ### Human Primary Kidney Fibroblasts - Myofibroblast activation​ - Profibrotic signaling​ - Kidney Inflammation ​ - Metabolic stress and mitochondrial injury # Established GLP Validation in Renal Biomakers As part of its expanding kidney disease focus, SBH Sciences has already completed GLP validation of nine kidney-specific biomarkers. These assays have been optimized for precision, sensitivity, and reproducibility to support regulated development pathways. ![Screenshot 2026-02-11 at 4.56.32 PM](https://sbhsciences.com/hs-fs/hubfs/Screenshot%202026-02-11%20at%204.56.32%20PM.png?width=900&height=574&name=Screenshot%202026-02-11%20at%204.56.32%20PM.png "Screenshot 2026-02-11 at 4.56.32 PM") ## Validation Parameters - Precision - Linearity (Accuracy) - Sensitivity - Reproducibility - Stability - Specificity (Cross Reactivity) - Interference (Matrix Effect) - Reference Range ## *Case study examples*Biomarker Difference Analysis Between Healthy and Diseased Patients Click the tabs to see data from different biomarkers.  See below for our full list of biomarkers we can test. [Clusterin](https://sbhsciences.com/kidney#clusterin-widget_17731709458651) [Cystatin C](https://sbhsciences.com/kidney#cystatin-c-widget_17731709458652) [KIM-1](https://sbhsciences.com/kidney#kim-1-widget_17731709458653) [NGAL](https://sbhsciences.com/kidney#ngal-widget_17731709458654) ![Screenshot 2026-02-11 at 4.56.08 PM](https://sbhsciences.com/hs-fs/hubfs/Screenshot%202026-02-11%20at%204.56.08%20PM.png?width=700&height=405&name=Screenshot%202026-02-11%20at%204.56.08%20PM.png) ![Screenshot 2026-03-10 at 3.25.25 PM](https://sbhsciences.com/hs-fs/hubfs/Screenshot%202026-03-10%20at%203.25.25%20PM.png?width=700&height=292&name=Screenshot%202026-03-10%20at%203.25.25%20PM.png) ![Screenshot 2026-03-10 at 3-25-34 PM](https://sbhsciences.com/hs-fs/hubfs/Screenshot%202026-03-10%20at%203-25-34%20PM.png?width=960&height=542&name=Screenshot%202026-03-10%20at%203-25-34%20PM.png) ![Screenshot 2026-03-10 at 3.25.56 PM](https://sbhsciences.com/hs-fs/hubfs/Screenshot%202026-03-10%20at%203.25.56%20PM.png?width=700&height=358&name=Screenshot%202026-03-10%20at%203.25.56%20PM.png) # Biofluid Protein Biomarkers | Biomarker | Indication | Biofluid | | --- | --- | --- | | **Nephrin (NPHS1)** | **Glomerular Injury** | **Urine** | | **Podocalyxin (PODXL)** | **Glomerular Injury** | **Urine** | | **APOL1 protein** | **Glomerular Injury** | **Urine/Plasma** | | **Synaptopodin** | **Glomerular Injury** | **Urine** | | **KIM-1 (HAVCR1)** | **Proximal Tubule Injury** | **Urine** | | **NGAL (LCN2)** | **Proximal Tubule Injury** | **Urine/Plasma** | | **Clusterin** | **Proximal Tubule Injury** | **Urine** | | **IL-18** | **Proximal Tubule Injury** | **Urine** | | **NAG** | **Proximal Tubule Injury** | **Urine** | | **PRO-C3** | **Fibrosis and Remodeling** | **Plasma** | | **PRO-C6** | **Fibrosis and Remodeling** | **Plasma** | | **TIMP-1** | **Fibrosis and Remodeling** | **Plasma/Urine** | | **MMP-2/MMP-9** | **Fibrosis and Remodeling** | **Plasma/Urine** | | **Galectin-3** | **Fibrosis and Remodeling** | **Plasma** | | **CTGF (CCN2)** | **Fibrosis and Remodeling** | **Plasma/Urine** | | **CCL2 (MCP-1)** | **Inflammation/Immune** | **Urine** | | **CXCL10 (IP-10)** | **Inflammation/Immune** | **Urine** | | **sCD163** | **Inflammation/Immune** | **Urine** | | **IL-6** | **Inflammation/Immune** | **Urine** | # Kidney-Specific Urinary Extracellular Vesicle (EV)-Based Biomarkers | | Cell of Origin | Disease | | --- | --- | --- | | **Podosin (NPHS2)** | **Podocyte** | **FSGS, DKD** | | **Synaptopodin** | **Podocyte** | **FSGS, DKD** | | **WT1** | **Podocyte** | **DKD, IgAN** | | **Na⁺/K⁺-ATPase α1 (ATP1A1)** | **Proximal Tubule ** | **DKD** | | **NCC (SLC12A3)** | **Distal tubule** | **CKD** | | **AQP1** | **Proximal tubule** | **DKD, ADPKD** | | **AQP2** | **Collecting duct** | **ADPKD** | | **miR-21** | **Fibroblast EV** | **CKD fibrosis** | | **miR-29** | **Fibroblast EV** | **Anti-fibrotic response** | | **miR-192** | **PTEC EV** | **DKD metabolic stress** | | **miR-146a** | **Immune EV** | **LN, IgAN** | # **Fast, Reliable Clinical Sample Processing** 650+ biomarkers available now for analysis at our CLIA and GCLP certified diagnostic laboratory with 12 precision analysis platforms.  [Learn More](https://sbhsciences.com/contact) ### Sign up for our newsletter! 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