ChatGPT Image Jan 27, 2026, 03_59_01 PM

Our Translational Research Platform for Metabolic Disease

Talk to an Expert

SBH SCIENCESMetabolic Disease Research Center

We partner with industry and academic institutions to support drug development across a broad range of metabolic disorders and MASH by providing comprehensive disease modeling state-of-the-art functional assays, and biomarker discovery and development services.

 

Our In-Vitro Models, Biomarker Platforms, and Functional Assays

We have developed a platform of functional assays in a growing range of in vitro models to support drug development programs for key indications in metabolic disease drug development including:

  • Insulin Resistance & Type 2 Diabetes
  • Obesity & Adipose Dysfunction
  • Metabolic Syndrome
  • MASH/MASLD
  • Advanced MASH & Fibrosis
ChatGPT Image Jan 27, 2026, 04_27_53 PM
Screenshot 2026-01-27 at 5-31-02 PM-1-1
3T3-L1 Preadipocytes/
Adipocytes
  • Adipocyte Differentiation (Adipogenesis) Assay​
  • Insulin-Stimulated Glucose Uptake Assay​
  • Lipolysis and Lipid Mobilization Assay​
  • Adipokine Secretion Profiling​
  • Mitochondrial Function & Energy Metabolism Assay​
  • Inflammation-Induced Insulin Resistance Assay

Screenshot 2026-01-27 at 5-33-59 PM

Hepatocytes
(primary & cell lines)

  • Hepatotoxicity & Cellular Stress Response​
  • Lipid Metabolism & Steatosis​
  • Glucose Metabolism & Insulin Signaling​
  • Bile Acid Transport & Cholestasis Risk​
  • Inflammation, ER Stress & Fibrotic Signaling
Screenshot 2026-01-27 at 5-51-10 PM-1

Pancreatic β-cells

  • Glucose-Stimulated Insulin Secretion​
  • Insulin Content & Processing​
  • Calcium Signaling​
  • Mitochondrial Function & Bioenergetics​
  • β-Cell Survival & Stress Response

Biofluid Protein Biomarkers

Biomarker Indication
IGF-1 Insulin Resistance & Glycemic Control​
Adiponectin Adipose Dysfunction
Leptin Adipose Dysfunction
hsCRP Systemic Inflammation
IL-6 Systemic Inflammation
TNF-α Systemic Inflammation
CK-18 (M30/M65) Hepatocyte Injury/ Apoptosis
PIIINP Fibrosis & ECM Remodeling
sCD163 Hepatic Inflammation
Galectin-3

Hepatic Inflammation/Fibrosis
FGF21 Metabolic Stress Hormone
MMP-2/MMP-9 Fibrosis and Remodeling