--- title: MUSCLE description: translational muscle disease research with assays, muscle biomarkers, cell based models for muscular dystrophy, cachexia, sarcopenia, inflammatory myopathy --- [![SBH Sciences](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/sbhlogo.png?width=155&height=74&name=sbhlogo.png "SBH Sciences")](https://sbhsciences.com/) - Open submenu for ABOUT US - [ABOUT SBH](https://sbhsciences.com/about-sbh) - [LEADERSHIP](https://sbhsciences.com/sbh-leadership) - [CONTACT](https://sbhsciences.com/contact) - [CAREERS](https://sbhsciences.com/careers) - [SBH BIOVENTURE](https://sbhsciences.com/sbh-bioventure) - [SOLUTIONS](https://sbhsciences.com/services) Show submenu for SOLUTIONS - [CELL BASED ASSAYS](https://sbhsciences.com/cell-based-assay-services) - Open submenu for PRODUCT SERVICES - [PROTEINS](https://sbhsciences.com/protein-production-services) - [MOLECULAR BIOLOGY](https://sbhsciences.com/molecular-biology-services) - [CELL CULTURE](https://sbhsciences.com/cell-culture-services) - 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[MONOCLONAL ANTIBODIES](https://sbhsciences.com/monoclonal-antibodies) - [GLYCOBIOLOGY](https://sbhsciences.com/glycobiology) - Open submenu for INSIGHTS - [NEWS AND BLOG](https://sbhsciences.com/sbh-blog-and-news) - [REFERENCES AND PUBLICATIONS](https://sbhsciences.com/references) - [STRATEGIC PARTNERSHIPS](https://sbhsciences.com/partnerships) Search Search Search Search ![ChatGPT Image Jan 21, 2026, 05\_58\_39 PM](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2021%2c%202026%2c%2005_58_39%20PM.png) # Our Translational Research Platform for Muscle Disease [Talk to an Expert](https://sbhsciences.com/contact) ## *SBH SCIENCES*Muscle Disease Research Center ### *We partner with industry and academic institutions to support drug development across a broad range of muscle disease indications by providing comprehensive disease modeling* *state-of-the-art functional assays,* *and biomarker discovery and development* *services.*   ## Our In-Vitro Models, Biomarker Platforms, and Functional Assays We have developed a platform of functional assays in a growing range of in vitro models to support drug development programs for key indications in muscle drug development including: - Duchenne Muscular Dystrophy (DMD) - Facioscapulohumeral Muscular Dystrophy (FSHD) - Myotonic Dystrophy (DM) - Cachexia & Sarcopenia - Inflammatory Myopathies ![ChatGPT Image Jan 16, 2026, 12\_58\_43 PM](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2016%2c%202026%2c%2012_58_43%20PM.png "ChatGPT Image Jan 16, 2026, 12_58_43 PM") ### C2C12 Myoblast / Myotube Model - Fusion Index - Myotube Formation​ - Myotube Diameter - Hypertrophy​ - Sarcomere Assembly​ - Creatine Kinase–MM – Muscle injury​ - Protein translation and synthesis and translational mechanisms ​ - Mitochondrial function​ - Cell signaling  ### Human Primary Skeletal Muscle Cells Model - Human Fiber Growth and Atrophy​ - Human Muscle Damage and Necrosis​ - Human Muscle Regeneration​ - Human Muscle metabolism​ - Human Muscle Mitochondrial function​ - Human Muscle Cachexia and Inflammatory Atrophy​ - Muscle disease markers panel ### Human Skeletal Muscle Satellite Cells (HSkMSC) model - Satellite Cells Regeneration – Human repair​ - Satellite-Cells Aging and Senescence​ - Satellite-Cells Colony formation​ - Satellite-Cells Migration ### Additional Models - Mouse Primary Skeletal Muscle Cells​ - Human Skeletal Muscle Cells (myoblast-enriched) # Biofluid Protein Biomarkers | Biomarker | DMD | Cachexia | Sarcopenia | Mitochondrial Metabolic Myopathies | Inflammatory Myopathies | Regeneration and Repair Disorders | | --- | --- | --- | --- | --- | --- | --- | | **Creatine Kinase-MM** | | | | | | | | **FABP3** | | | | | | | | **IGF-1** | | | | | | | | **Myostatin** | | | | | | | | **Follistatin** | | | | | | | | **GDF-15** | | | | | | | | **FGF21** | | | | | | | | **IL-6** | | | | | | | | **TNF-α** | | | | | | | | **Pro-BDNF** | | | | | | | | **Myonectin** | | | | | | | | **Irisin** | | | | | | | # Muscle-Specific Extracellular Vesicle (EV)-Based RNA Biomarkers | Biomarker | DMD | Cachexia | Sarcopenia | Mitochondrial Metabolic Myopathies | Inflammatory Myopathies | Regeneration and Repair Disorders | | --- | --- | --- | --- | --- | --- | --- | | **miR-1-3p** | | | | | | | | **miR-133a-3p** | | | | | | | | **miR-206-3p** | | | | | | | | **miR-486-5p** | | | | | | | | **miR-208b-3p** | | | | | | | | **miR-499-5p** | | | | | | | | **IL6 mRNA** | | | | | | | | **TNFA mRNA** | | | | | | | | **FGF21 mRNA** | | | | | | | # **Fast, Reliable Clinical Sample Processing** 600+ biomarkers available now for analysis at our CLIA and GCLP certified diagnostic laboratory with 12 precision analysis platforms.  [Learn More](https://sbhsciences.com/contact) ### Sign up for our newsletter! **Discovery Research Products & Services** (508) 650-6218 | [Inquiries@SBHsciences.com](mailto:Inquiries@SBHsciences.com) The World's Leading Provider of Cytokine Cell-Based Assays Recombinant Cytokines, Enzymes, Antibodies, Cell-Based Assay and Innovative Process Development Solutions **[COMPANY](https://sbhsciences.com/about-sbh)** [About Us](https://sbhsciences.com/about-sbh) [SBH Leadership](https://sbhsciences.com/sbh-leadership) [Company Presentation](https://sbhsciences.com/hubfs/43587181/SBH_Presentation.pdf) [Strategic Partnerships](https://sbhsciences.com/partnerships) [References and Publications](https://sbhsciences.com/references) [News and Blog](https://sbhsciences.com/sbh-blog-and-news) [Careers](https://sbhsciences.com/careers) [Request a Quote](https://sbhsciences.com/contact) [Contact Us](https://sbhsciences.com/contact) **[SERVICES](https://sbhsciences.com/services)** [Automated Western Blot](https://sbhsciences.com/platform-technologies#wb) [Bioanalytical](https://sbhsciences.com/bioanalytical-discovery-services) [Biomarker Testing](https://sbhsciences.com/biomarker-testing) [Cell-Based Assay](https://sbhsciences.com/cell-based-assay-services) [Cell Culture Services](https://sbhsciences.com/cell-culture-services) [Cell & Gene Therapy (CGT)](https://sbhsciences.com/cgt) [Small Molecule](https://sbhsciences.com/small-molecule) [Biosimilars](https://sbhsciences.com/biosimilars) [Antibody Development](https://sbhsciences.com/antibody-development-1) [ELISA Services](https://sbhsciences.com/elisa-assays) [Molecular Biology](https://sbhsciences.com/molecular-biology-services) [Organoids](https://sbhsciences.com/blog/organoids-mini-organs-grown-for-research-and-drug-development) [Exosomes](https://sbhsciences.com/exosome-services) [Protein Purification/Production](https://sbhsciences.com/protein-production-services) [FTE Scientist Model](https://sbhsciences.com/fte-model) [Consulting](https://sbhsciences.com/mentoring) **INDICATIONS** [Oncology](https://sbhsciences.com/oncology) [Kidney](https://sbhsciences.com/kidney) [Muscle](https://sbhsciences.com/muscle) [Metabolic](https://sbhsciences.com/metabolic) [Neurology](https://sbhsciences.com/neurology) **[PRODUCTS](https://sbhsciences.com/products)** [Request a Quote](https://sbhsciences.com/contact) [Cytokines](https://sbhsciences.com/cytokines) [Monoclonal Antibodies](https://sbhsciences.com/monoclonal-antibodies) [Glycobiology](https://sbhsciences.com/glycobiology) **[SBH Bioventure](https://sbhsciences.com/sbh-bioventure)** [**SBH Diagnostics**](https://sbhdiagnostics.com/#)   [![linkedin](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/linkedin.gif?width=45&height=44&name=linkedin.gif)](https://www.linkedin.com/company/sbh-sciences)     ©2026 SBH Sciences. 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