Our Translational Research Platform for Muscle Disease
SBH SCIENCESMuscle Disease Research Center
We partner with industry and academic institutions to support drug development across a broad range of muscle disease indications by providing comprehensive disease modeling state-of-the-art functional assays, and biomarker discovery and development services.
Our In-Vitro Models, Biomarker Platforms, and Functional Assays
We have developed a platform of functional assays in a growing range of in vitro models to support drug development programs for key indications in muscle drug development including:
- Duchenne Muscular Dystrophy (DMD)
- Facioscapulohumeral Muscular Dystrophy (FSHD)
- Myotonic Dystrophy (DM)
- Cachexia & Sarcopenia
- Inflammatory Myopathies
C2C12 Myoblast / Myotube Model
- Fusion Index - Myotube Formation
- Myotube Diameter - Hypertrophy
- Sarcomere Assembly
- Creatine Kinase–MM – Muscle injury
- Protein translation and synthesis and translational mechanisms
- Mitochondrial function
- Cell signaling
Human Primary Skeletal Muscle Cells Model
- Human Fiber Growth and Atrophy
- Human Muscle Damage and Necrosis
- Human Muscle Regeneration
- Human Muscle metabolism
- Human Muscle Mitochondrial function
- Human Muscle Cachexia and Inflammatory Atrophy
- Muscle disease markers panel
Human Skeletal Muscle Satellite Cells (HSkMSC) model
- Satellite Cells Regeneration – Human repair
- Satellite-Cells Aging and Senescence
- Satellite-Cells Colony formation
- Satellite-Cells Migration
Additional Models
- Mouse Primary Skeletal Muscle Cells
- Human Skeletal Muscle Cells (myoblast-enriched)
Biofluid Protein Biomarkers
| Biomarker | DMD | Cachexia | Sarcopenia | Mitochondrial Metabolic Myopathies | Inflammatory Myopathies | Regeneration and Repair Disorders |
|---|---|---|---|---|---|---|
| Creatine Kinase-MM | ||||||
| FABP3 | ||||||
|
IGF-1 |
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| Myostatin | ||||||
| Follistatin | ||||||
| GDF-15 | ||||||
| FGF21 | ||||||
| IL-6 | ||||||
| TNF-α | ||||||
| Pro-BDNF | ||||||
| Myonectin | ||||||
| Irisin |
Muscle-Specific Extracellular Vesicle (EV)-Based RNA Biomarkers
| Biomarker | DMD | Cachexia | Sarcopenia | Mitochondrial Metabolic Myopathies | Inflammatory Myopathies | Regeneration and Repair Disorders |
|---|---|---|---|---|---|---|
| miR-1-3p | ||||||
| miR-133a-3p | ||||||
|
miR-206-3p |
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|
miR-486-5p |
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| miR-208b-3p | ||||||
| miR-499-5p | ||||||
|
IL6 mRNA |
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| TNFA mRNA | ||||||
| FGF21 mRNA |