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Recombinant Human Activin-A

Activin-A Applications

Description :

Activin-A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin-A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin-A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin-A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.

Catalog #:

003-ACTIVINa

Source :

High-5 (BTI-Tn-5B1-4) Insect Cells

Formulation :

The sterile filtered solution was lyophilized from 50 mM Citric Acid, pH 3.0.

Stability :

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -800C.
Reconstituted Human Activin-A should be stored in working aliquots at -800C.

Purity :

Greater than 95% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Reconstitution :

We recommend a quick spin followed by reconstitution in water to a concentration of 50 μg/ml (e.g., 5 μg/100μl) will yield a solution of 10 mM Citric Acid, pH 3.0. This solution can then be stored at room temperature or at 40C for 1 month. It is recommended that further dilutions be made in PBS containing 2 mg/ml albumin and stored at -800C.

Biological Activity :

The ED50 was determined by ability to inhibit the murine MPC-11 cells. The expected ED50 is 0.5 - 2.0 ng/ml.

PubMed  Link :

Activin-A Human

Usage:

For research Purposes Only - Made using a cell BTI-Tn-5B1-4 under license from the Boyce Thompson Institute for Plant Research, Inc. Not for use in diagnostic or therapeutic procedures.

Country of Origin :

USA



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