Recombinant Human CD22

CD22 Applications

Description :

CD22 is a 135 kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2-6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advance stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkin's lymphoma and certain autoimmune conditions. (Cesano A. and Gayko U. Semin. Oncol. Apr. 2003 (2): 253-257). Recombinant human CD22 is a soluble 75.0 kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22.

Catalog #:


Source :

CHO cells (Chinese Hamster Ovarian cells)

Formulation :

The sterile filtered solution was lyophilized from 1 x PBS, pH 7.2

Stability :

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -200C. Reconstituted CD22 should be stored in working aliquots at -200C.

Purity :

Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Reconstitution :

We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 40C for 1 week or stored at -200C for future use.

Biological Activity :

Determined by it's ability to induce cytotoxicity in Raji cells. The ED50 for this effect is 10 - 15 ug/ml.

PubMed  Link :

Human CD22


For research only. Not for use in diagnostic or therapeutic procedures.

Country of Origin :


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