--- title: Oncology description: oncology translational drug discovery, in-vitro cytotoxicity testing, lead optimization and functional biology biomarker panels for anti-cancer drugs --- [![SBH Sciences](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/sbhlogo.png?width=155&height=74&name=sbhlogo.png "SBH Sciences")](https://sbhsciences.com/) - Open submenu for ABOUT US - [ABOUT SBH](https://sbhsciences.com/about-sbh) - [LEADERSHIP](https://sbhsciences.com/sbh-leadership) - [CONTACT](https://sbhsciences.com/contact) - [CAREERS](https://sbhsciences.com/careers) - [SBH BIOVENTURE](https://sbhsciences.com/sbh-bioventure) - [SOLUTIONS](https://sbhsciences.com/services) Show submenu for SOLUTIONS - [CELL BASED ASSAYS](https://sbhsciences.com/cell-based-assay-services) - Open submenu for PRODUCT SERVICES - [PROTEINS](https://sbhsciences.com/protein-production-services) - [MOLECULAR BIOLOGY](https://sbhsciences.com/molecular-biology-services) - [CELL CULTURE](https://sbhsciences.com/cell-culture-services) - 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Access a library of 50+ approved cancer drugs to test compounds alone or in combination. Pair these studies with in vitro cytotoxicity assays to generate actionable data for early oncology drug development and compound prioritization. Compound Screening Multi-Cell Line Testing Cytotoxicity Analysis ![Screenshot 2026-02-03 at 10.15.16 AM](https://sbhsciences.com/hubfs/Screenshot%202026-02-03%20at%2010.15.16%20AM.png) ## *TEST FASTER. COMPARE EASIER. DISCOVER MORE.* Compare, Combine and Validate Against 50+ Proven Cancer Drugs Access a curated panel of approved and investigational oncology drugs for immediate comparison and combination studies, alongside testing across **380 human cancer cell lines**.  ![Screenshot 2026-08-24 at 2.23.59 PM](https://sbhsciences.com/hubfs/Screenshot%202026-08-24%20at%202.23.59%20PM.png) ## *WITH BONDS BIOSYSTEMS* 2D and 3D Tumor Modeling We support customized oncology studies using advanced **3D tumor models**, including tumor spheroids and patient-derived tumor organoids (PDOs), through our collaboration with BOND Biosystems. These models can be combined with cancer cell lines, primary cells, genetically engineered models, and tumor–microenvironment co-culture systems to better capture tumor biology and therapeutic response. **Capabilities include:** - 3D tumor spheroids & PDOs - 2D cancer cell & primary cell models - Genetically engineered models - Tumor–microenvironment co-cultures - Drug response & efficacy profiling - Integrated biomarker and immune profiling ## Lead Drug Optimization and Peptide Therapeutics Development Capabilites - Cyclization - Biotinylation - Phosphorylation - Glycosylation - Binding of specific small MW toxic-drugs - Non-radioactive Cytotoxicity Assays (Multi-Tox Glo & ApoGlow ![ChatGPT Image Feb 3, 2026, 01\_19\_35 PM-1](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%203%2c%202026%2c%2001_19_35%20PM-1.png?width=400&height=395&name=ChatGPT%20Image%20Feb%203%2c%202026%2c%2001_19_35%20PM-1.png "ChatGPT Image Feb 3, 2026, 01_19_35 PM-1") # Cancer Drugs Available for Research Purposes - Adrucil - Fluorouracil (5FU) - Artesunate - Artemisinin - Avastin - Bortezomib (Valcade) - Camptothecin - Carboplatin - Cyclophosphamide (Cytoxan) - [Cisplatin, Cisplatinum Orcis- Diamminedichloroplatinum (II) (data)](https://sbhsciences.com/hubfs/sbh_graphs/mcf7.gif) - Dasatinib - [Doxorubicin (data)](https://sbhsciences.com/hubfs/sbh_graphs/hepg2dox.gif) - [Erlotinib (data)](https://sbhsciences.com/hubfs/sbh_graphs/hepg2e.gif) - Etoposide - Gefitinib (Iressa) - Gemcitabine Hydrochloride - Imatinib (Gleevec) - Irinotecan HCl - Ifosfamide - Leptomycin B - [Mitomycin C (data)](https://sbhsciences.com/hubfs/sbh_graphs/mitoc.gif) - Neomycin Sulfate - a-Solanine - Paclitaxel (Taxol) - Sorafenib - Staurosporine - Tamoxifen - Tomatine - Vinblastine - Vincristine ## Oncology Biomarker Panels Designed for Early Drug Development #### Apoptosis and Epithelial Tumors | **Biomarker** | **Cancer ** | **Role** | | --- | --- | --- | | Cleaved Cytokeratin 18 (M30) | Breast, colon, liver | Apoptotic epithelial cell marker | | Cytokeratin 18 (total) | Breast, colon, liver | Total epithelial cell death | | Caspase 3/7 Activity | Broad solid tumors | Apoptotic pathway activation | | High Mobility Group Box 1 (HMGB1) | Various solid tumors | Marker of tumor cell death/necrosis | | Galectin-3 | Thyroid, breast, colorectal | Tumor progression and immune evasion | #### Angiogenesis and Tumor Growth | **Biomarker** | **Cancer ** | **Notes** | | --- | --- | --- | | VEGF-A | Breast, colon, renal, lung | Key angiogenesis driver | | VEGF-C | Breast, colorectal | Lymphangiogenesis | | VEGF-D | Various solid tumors | Lymphatic metastasis potential | | VEGFR1 | Solid tumors | VEGF receptor; targetable | | PDGF-AA/AB/BB | Glioblastoma, sarcoma, pancreatic | Tumor growth and stromal activation | | FGF-basic | Breast, colon, melanoma | Angiogenesis | | PIGF | Solid tumors | Tumor vascular remodeling | | Tie-2 | Tumor vasculature | Endothelial activation marker | #### Immuno-Oncology and Tumor Microenvironment | **Biomarker** | **Cancer ** | **Notes** | | --- | --- | --- | | 4-1BB (CD137) | Solid tumors, immunotherapy | T-cell co-stimulation, checkpoint target | | Granzyme B | Broad solid tumors | Cytotoxic T-cell activity | | Perforin | Solid tumors | T/NK cell-mediated tumor killing | | Galectin-1 | Glioblastoma, pancreatic | Tumor immune evasion | | TNF-α | Various | Inflammatory marker, tumor progression | | IL-6 | Lymphoma, breast, prostate | Chronic inflammation, tumor-promoting | | IL-8 | Melanoma, ovarian, lung | Angiogenesis, metastasis | | MCP-1 (CCL2) | Breast, prostate, ovarian | Tumor-associated macrophage recruitment | | MIP-1β (CCL4) | Tumor microenvironment | Immune cell recruitment | | TARC (CCL17) | Hodgkin lymphoma | Immune microenvironment | #### Inflammation and Tumor Progression | **Biomarker** | **Cancer ** | **Notes** | | --- | --- | --- | | CRP | Various cancers | General inflammation | | SAA | Breast, lung | Acute phase protein elevated in tumor progression | | ICAM-1 / VCAM-1 | Metastatic tumors | Endothelial activation, metastasis potential | | TGF-β1 | Breast, colon, pancreatic | Tumor progression, immune modulation | | TGF-α | EGFR-driven tumors | Tumor proliferation | | Galectin-1 | Solid tumors | Immune evasion | #### Hematologic and Multiple Myeloma | **Biomarker** | **Cancer ** | **Notes** | | --- | --- | --- | | Beta-2-Microglobulin | Multiple myeloma, lymphoma | Disease progression marker | | Fms-Related Tyrosine Kinase 3 Ligand (Flt3L) | Leukemia | Hematopoietic growth, prognosis | | IL-1β, IL-10, IL-12p70 | Leukemia, lymphoma | Immune modulation | | TNF-β | Lymphoma | Immune/inflammatory context | ## Biomarkers Organized by Cancer Type While our functional biology–based oncology panels group biomarkers by pathway and mechanism of action, many programs are organized around specific tumor indications. To support indication-driven development strategies, we also provide a comprehensive listing of our oncology biomarkers organized by cancer type, making it easy to align panel selection with your therapeutic focus.  [Download PDF](https://sbhsciences.com/hubfs/Our%20Cancer%20Panels-1.pdf) [![Our Cancer Panels](https://sbhsciences.com/hs-fs/hubfs/Our%20Cancer%20Panels.png?width=300&height=388&name=Our%20Cancer%20Panels.png "Our Cancer Panels")](https://sbhsciences.com/hubfs/Our%20Cancer%20Panels-1.pdf) # **Fast, Reliable Clinical Sample Processing** 650+ biomarkers available now for analysis at our CLIA and GCLP certified diagnostic laboratory with 12 precision analysis platforms.  [Learn More](https://sbhsciences.com/contact) ## From Discovery to IND: Oncology Solutions ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-1](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-1.png?width=100&height=65&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-1.png) ### Biomarkers ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-2-1](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-2-1.png?width=127&height=64&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-2-1.png) ### Bioassays ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-3-1](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-3-1.png?width=100&height=66&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-3-1.png) ### Cytokines ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-4](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-4.png?width=70&height=63&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-4.png) ### mAbs ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-Feb-06-2026-09-06-47-8201-PM](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-06-47-8201-PM.png?width=100&height=66&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-06-47-8201-PM.png) ### Bioanalysis ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-Feb-06-2026-09-07-33-6836-PM](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-07-33-6836-PM.png?width=87&height=67&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-07-33-6836-PM.png) ### Cell & Gene Therapy ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-Feb-06-2026-09-08-15-7797-PM](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-08-15-7797-PM.png?width=80&height=66&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-08-15-7797-PM.png) ### Small Molecule ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-Feb-06-2026-09-08-50-3909-PM](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-08-50-3909-PM.png?width=95&height=66&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-08-50-3909-PM.png) ### Antibody Development ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-Feb-06-2026-09-10-52-1925-PM](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-10-52-1925-PM.png?width=100&height=60&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-10-52-1925-PM.png) ### Biosimilars ![ChatGPT Image Feb 6, 2026, 03\_55\_50 PM-Feb-06-2026-09-10-14-1794-PM](https://sbhsciences.com/hs-fs/hubfs/ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-10-14-1794-PM.png?width=80&height=67&name=ChatGPT%20Image%20Feb%206%2c%202026%2c%2003_55_50%20PM-Feb-06-2026-09-10-14-1794-PM.png) ### Molecular Diagnostics # High Impact Anti-Cancer Drug Screening SBH Sciences is actively collaborating with [Karyopharm Therapeutics](https://www.karyopharm.com/) on its anti-cancer development program. We have used over 200 cancer cell lines in this collaboration and are continuing to screen for promising anti-cancer drugs. SBH Sciences and Karyopharm Therapeutics have presented 10 scientific abstracts together. 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