Exosome Analysis for Liquid Biopsy and Biomarker Discovery
Unlock deeper biological insights with exosome-based biomarkers. SBH Sciences supports isolation, characterization, and multi-platform analysis to accelerate translational and clinical research.


Tiny Messengers of Disease
Exosomes are small (30–200 nm), cell-derived extracellular vesicles that carry proteins, nucleic acids, and lipids reflective of their cell of origin, playing a critical role in cell-to-cell communication. Found in biofluids such as blood, urine, and saliva—as well as in cell culture media—they can be isolated through minimally invasive methods, making them highly valuable for liquid biopsy applications. Their molecular cargo varies by cell type and disease state, enabling insights into conditions like cancer, neurodegenerative, metabolic, and infectious diseases. As a result, exosomes have emerged as powerful tools for biomarker discovery, diagnostics, and therapeutic development, with rapidly growing interest in both clinical research and drug delivery.
SBH Exosome Services
Isolation and Purification
- Polymer Precipitation
- Ion-Exchange Chromatography
- Size-Exclusion Chromatography
- Immunoaffinity
Exosomes can be isolated from liquid biopsy samples, cell culture media or directly from SBH's library of 500+ mammalian cell lines and 370 human cancer cell lines.
Characterization
DNA: qPCR, dPCR, isothermal amplification
RNA: gene expression analysis (RT-qPCR)
Bioanalytical
Proteins: Western Blot, ELISA/Luminex
Flow cytometry
Functional Cell-Based Assays
Cell proliferation
Cytotoxicity
Immunomodulation
Cell migration
Applications
- Predictive Biomarkers
- Prognostic Biomarkers
- Drug Delivery
- mRNA Delivery
- Liquid Biopsy
- Vaccine Development
Why Choose SBH for Exosome Research Support?
-1.png)
To learn more about leveraging exosomes for precision biomarker discovery, contact SBH Sciences and start a conversation with our scientific team.
References
Krol, T. et al. Exosomes – The Good, Bad, Ugly and Current State. American Pharmaceutical Review. Monday, April 26, 2021.
Raghu, K and LeBleu, VS. The biology, function, and biomedical applications of exosomes.
Science. 2020 February 07; 367(6478): . doi:10.1126/science.aau6977
Tai, Y-L et al. Exosomes in cancer development and clinical applications. Cancer Sci. 2018 Aug; 109(8): 2364–2374. doi: 10.1111/cas.13697
Sun, K. et al. Exosomes as CNS Drug Delivery Tools and Their Applications. Pharmaceutics. 2022 Oct; 14(10): 2252. doi: 10.3390/pharmaceutics14102252
Kaddour, H. et al. The Past, the Present, and the Future of the Size Exclusion Chromatography in Extracellular Vesicles Separation. Viruses. 2021 Nov; 13(11): 2272. doi: 10.3390/v13112272
Khushman, M. et al. Exosomal Markers (CD63 and CD9) Expression Pattern Using Immunohistochemistry in Resected Malignant and Non-malignant Pancreatic Specimens. Pancreas. 2017 Jul; 46(6): 782-788. doi: 10.1097/MPA.0000000000000847
