--- title: Inflammation description: SBH offers several In-Vitro inflammation models. --- [![SBH Sciences](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/sbhlogo.png?width=155&height=74&name=sbhlogo.png "SBH Sciences")](https://sbhsciences.com/) - Open submenu for ABOUT US - [ABOUT SBH](https://sbhsciences.com/about-sbh) - [LEADERSHIP](https://sbhsciences.com/sbh-leadership) - [CONTACT](https://sbhsciences.com/contact) - [CAREERS](https://sbhsciences.com/careers) - [SBH BIOVENTURE](https://sbhsciences.com/sbh-bioventure) - [SOLUTIONS](https://sbhsciences.com/services) Show submenu for SOLUTIONS - [CELL BASED ASSAYS](https://sbhsciences.com/cell-based-assay-services) - Open submenu for PRODUCT SERVICES - [PROTEINS](https://sbhsciences.com/protein-production-services) - [MOLECULAR BIOLOGY](https://sbhsciences.com/molecular-biology-services) - [CELL CULTURE](https://sbhsciences.com/cell-culture-services) - [ORGANOIDS](https://sbhsciences.com/blog/organoids-mini-organs-grown-for-research-and-drug-development) - [EXOSOMES](https://sbhsciences.com/exosome-services) - [BIOMARKER TESTING](https://sbhsciences.com/biomarker-testing) - Open submenu for DRUG DISCOVERY - [ADCC](https://sbhsciences.com/antibody-development-1) - [ELISA](https://sbhsciences.com/elisa-assays) - [BIOANALYTICAL](https://sbhsciences.com/bioanalytical-discovery-services) - [BIOSIMILARS](https://sbhsciences.com/biosimilars) - [CELL & GENE THERAPY](https://sbhsciences.com/cgt) - [SMALL MOLECULE](https://sbhsciences.com/small-molecule) - [FTE MODEL](https://sbhsciences.com/fte-model) - [CONSULTING](https://sbhsciences.com/mentoring) - Open submenu for INDICATIONS - [NEUROLOGY](https://sbhsciences.com/neurology) - [METABOLIC](https://sbhsciences.com/metabolic) - [ONCOLOGY](https://sbhsciences.com/oncology) - [KIDNEY](https://sbhsciences.com/kidney) - [MUSCLE](https://sbhsciences.com/muscle) - Open submenu for PRODUCTS - [CYTOKINES](https://sbhsciences.com/cytokines) - [MONOCLONAL ANTIBODIES](https://sbhsciences.com/monoclonal-antibodies) - [GLYCOBIOLOGY](https://sbhsciences.com/glycobiology) - Open submenu for INSIGHTS - [NEWS AND BLOG](https://sbhsciences.com/sbh-blog-and-news) - [REFERENCES AND PUBLICATIONS](https://sbhsciences.com/references) - [STRATEGIC PARTNERSHIPS](https://sbhsciences.com/partnerships) - Open submenu for ABOUT US - [ABOUT SBH](https://sbhsciences.com/about-sbh) - [LEADERSHIP](https://sbhsciences.com/sbh-leadership) - [CONTACT](https://sbhsciences.com/contact) - [CAREERS](https://sbhsciences.com/careers) - [SBH BIOVENTURE](https://sbhsciences.com/sbh-bioventure) - [SOLUTIONS](https://sbhsciences.com/services) Show submenu for SOLUTIONS - [CELL BASED ASSAYS](https://sbhsciences.com/cell-based-assay-services) - Open submenu for PRODUCT SERVICES - [PROTEINS](https://sbhsciences.com/protein-production-services) - [MOLECULAR BIOLOGY](https://sbhsciences.com/molecular-biology-services) - [CELL CULTURE](https://sbhsciences.com/cell-culture-services) - [ORGANOIDS](https://sbhsciences.com/blog/organoids-mini-organs-grown-for-research-and-drug-development) - [EXOSOMES](https://sbhsciences.com/exosome-services) - [BIOMARKER TESTING](https://sbhsciences.com/biomarker-testing) - Open submenu for DRUG DISCOVERY - [ADCC](https://sbhsciences.com/antibody-development-1) - [ELISA](https://sbhsciences.com/elisa-assays) - [BIOANALYTICAL](https://sbhsciences.com/bioanalytical-discovery-services) - [BIOSIMILARS](https://sbhsciences.com/biosimilars) - [CELL & GENE THERAPY](https://sbhsciences.com/cgt) - [SMALL MOLECULE](https://sbhsciences.com/small-molecule) - [FTE MODEL](https://sbhsciences.com/fte-model) - [CONSULTING](https://sbhsciences.com/mentoring) - Open submenu for INDICATIONS - [NEUROLOGY](https://sbhsciences.com/neurology) - [METABOLIC](https://sbhsciences.com/metabolic) - [ONCOLOGY](https://sbhsciences.com/oncology) - [KIDNEY](https://sbhsciences.com/kidney) - [MUSCLE](https://sbhsciences.com/muscle) - Open submenu for PRODUCTS - [CYTOKINES](https://sbhsciences.com/cytokines) - [MONOCLONAL ANTIBODIES](https://sbhsciences.com/monoclonal-antibodies) - [GLYCOBIOLOGY](https://sbhsciences.com/glycobiology) - Open submenu for INSIGHTS - [NEWS AND BLOG](https://sbhsciences.com/sbh-blog-and-news) - [REFERENCES AND PUBLICATIONS](https://sbhsciences.com/references) - [STRATEGIC PARTNERSHIPS](https://sbhsciences.com/partnerships) Search Search Search Search # Inflammation   #### SBH Sciences is offering In-Vitro models for Inflammation and Fibrosis \[NASH\]   SBH Sciences is offering several In-Vitro inflammation models. The first model is based on utilization of human PBMC and the secretion of human TNF-alpha as a result of LPS stimulation. ![inflamation](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/inflamation.gif?width=600&height=410&name=inflamation.gif) ![inflammation1](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/inflammation1.jpg?width=649&height=445&name=inflammation1.jpg) ![inflammation2](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/inflammation2.jpg?width=646&height=449&name=inflammation2.jpg) ![inflammation3](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/inflammation3.jpg?width=653&height=456&name=inflammation3.jpg) **Innovative Models** Liver (LX-2) / Lung (Beas-2B) / Heart models (induced pluripotent stem cells - iPSC) \- Macrophages activation M1 & M2 \- Functional assays (receptors-ligands interaction) \- Inflammatory Cytokines and Fibrosis Biomarkers \- Cytotoxicity – apoptosis **Biomarkers Platforms** \- ELISA / Receptor Binding Assay for biomarkers and metabolites \- Luminex / MSD / ELLA – multi-array biomarkers \- PeggySue, WES and Jess \- Flow cytometer \[FACS\] \- Isolight \- qRT-PCR **Markers** (partial list) TNF-a, MCP-1, IL-1b, TGF-beta, iNOS, Pro-Collagen, Galectin-3, TLRs, Integrins mRNA Analysis of Pro-Fibrotic Chemokines / Cytokines / Collagen for up and down-regulation in Fibrosis Model ![nash1](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/nash1.jpg?width=797&height=358&name=nash1.jpg) ![nash2](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/nash2.jpg?width=786&height=776&name=nash2.jpg) Effect of GR-MD-02 on cell culture model of macrophages: THP-1 cells treated with phorbol ester and endotoxin ![nash3](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/nash3.jpg?width=849&height=660&name=nash3.jpg) Expression of MCP-1 is reduced in dose dependent fashion in two separate GMP lots of GR-MD-02 while viability of THP-1 cells is maintained (compared to N-lactosamine—LacNac) Note: We have shown that Galectin-3 is expressed in THP-1 cells. There is also a reduction in TNF-alpha and IL-8 with treatment.   #### Contact SBH   Please [contact us](https://sbhsciences.com/contact) with your specific needs or any questions related to In-Vitro Inflammation investigation and anti-inflammation lead drug optimization. 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