ChatGPT Image Feb 10, 2026, 10_19_56 AM

Our Translational Research Platform for Neurological Disease

Talk to an Expert

SBH SCIENCESNeurological Disease Research Center

We partner with industry and academic institutions to support drug development across a broad range of neuroodegenerative disorders by providing comprehensive disease modeling state-of-the-art functional assays, and biomarker discovery and development services.

 

Our In-Vitro Models, Biomarker Platforms, and Functional Assays

We have developed a platform of functional assays in a growing range of in vitro models to support drug development programs for key indications in neurodegenerative disease drug development including:

  • Cognitive-Dominant Neurodegenerative Disorders
  • Movement-Dominant Neurodegenerative Disorders
  • Motor Neuron Diseases
  • Inflammatory Neurodegeneration
  • Rare and Genetic Neurodegenerative Disorders
ChatGPT Image Feb 10, 2026, 10_23_48 AM-1

Functional Assays

Primary Neurons and Neuroblastoma Cells

24-1

Cell Viability and Neuroprotection

24-2

Mitochondrial Function

24-3

Oxidative Stress

23-1

a-Synuclein Aggregation and Clearance

23-2-1

Apoptosis and Cell Death Pathways

24-4

Target Engagement and MOA Validation

22-1

Neuronal Differentiation

17-2

Autophagy Lysosomal Pathway

Biofluid Protein Biomarkers

Biomarker Indication Biofluid
p-Tau217

Tau Phosphorylation (AD Specific)

 Plasma, CSF
p-Tau181

Tau Pathology

 Plasma, CSF

p-Tau231

Early Tau Changes

 Plasma, CSF

Aβ42

Amyloid Pathology

 CSF
Aβ42/40 Ratio

Amyloid Burden

 Plasma, CSF

Total Tau (t-Tau)

Neuronal Injury

 CSF, Plasma

GFAP

 Astrocytic Activatioon Plasma, CSF

NFL

 Axonal Degeneration Plasma, CSF
Neurogranin Synaptic Loss CSF
SNAP-25 Synaptic Dysfunction CSF