Description
GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15/MIC-1 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.
Product Specific Information
Storage: Store in working aliquots at -20°C for long-term stability.
For research Purposes Only. Not for use in diagnostic or therapeutic procedures
| PROPERTIES | |
|---|---|
| Species | Human |
| Expression System | Human Cell Culture |
| Molecular Weight | 24.6 kDa |
| Full Length | 114 amino acids |
| Purity |
≥98% by SDS-PAGE and HPLC Analyses |
| Form | Lyophilized |
| Endotoxin | <1 EU/µg |
| Storage | -20°C |
