IGFBPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGFBP-2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGFBP-2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGFBP-2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGFBP domain and thyroglobulin type-I domain.
Product Specific Information
Storage: Reconstituted h-IGFBP-2 should be stored in working aliquots at -20°C.
| PROPERTIES | |
|---|---|
| Species | Human |
| Expression System |
High-5, Insect Cells |
| Molecular Weight | 25.8 kDa |
| Full Length | 237 amino acids |
| Purity |
≥98% by SDS-PAGE and HPLC Analyses |
| Form | Lyophilized |
| Endotoxin | <1 EU/µg |
| Activity |
Determined by its ability to inhibit IGF-I or IGF-II induced proliferation of FDC-P1 cells |
| Storage | -20°C |
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