CD22 is a 135 kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2-6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advanced stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkin’s lymphoma and certain autoimmune conditions. Recombinant human CD22 is a soluble 75.0 kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22.
Product Specific Information
Reconstitution: We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml.
Storage: Store at -20°C for long-term stability.
| PROPERTIES | |
|---|---|
| Species | Human |
| Expression System | Chinese Hamster Ovary (CHO) Cells |
| Molecular Weight | 75 kDa |
| Full Length | 666 amino acids |
| Purity |
≥98% by SDS-PAGE and HPLC Analyses |
| Form | Lyophilized |
| Endotoxin | <1 EU/µg |
| Activity | Determined by it's ability to induce cytotoxicity in Raji cells. The ED50 for this effect is 10 - 15 ug/ml |
| Storage | -20°C |