---
title: Human IL-4 Receptor Alpha (Soluble) Recombinant Protein
description: Activin-A is a TGF-beta family member involved in the regulation of cellular proliferation and differentiation, and promotion of neuronal survival.
---

<https://sbhsciences.com/blog/human-il-4-receptor-alpha-soluble-recombinant-protein#body>

[![SBH Sciences](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/sbhlogo.png?width=155&height=74&name=sbhlogo.png "SBH Sciences")](https://sbhsciences.com/)

- Open submenu for ABOUT US 
  
    - [ABOUT SBH](https://sbhsciences.com/about-sbh)
    - [LEADERSHIP](https://sbhsciences.com/sbh-leadership)
    - [CONTACT](https://sbhsciences.com/contact)
    - [CAREERS](https://sbhsciences.com/careers)
- [SBH BIOVENTURE](https://sbhsciences.com/sbh-bioventure)
- [SOLUTIONS](https://sbhsciences.com/services)
  
   Show submenu for SOLUTIONS 
  
    - [CELL BASED ASSAYS](https://sbhsciences.com/cell-based-assay-services)
    - Open submenu for PRODUCT SERVICES 
      
          - [PROTEINS](https://sbhsciences.com/protein-production-services)
          - [MOLECULAR BIOLOGY](https://sbhsciences.com/molecular-biology-services)
          - [CELL CULTURE](https://sbhsciences.com/cell-culture-services)
          - [ORGANOIDS](https://sbhsciences.com/blog/organoids-mini-organs-grown-for-research-and-drug-development)
          - [EXOSOMES](https://sbhsciences.com/exosome-services)
    - [BIOMARKER TESTING](https://sbhsciences.com/biomarker-testing)
    - Open submenu for DRUG DISCOVERY 
      
          - [ADCC](https://sbhsciences.com/antibody-development-1)
          - [ELISA](https://sbhsciences.com/elisa-assays)
          - [BIOANALYTICAL](https://sbhsciences.com/bioanalytical-discovery-services)
          - [BIOSIMILARS](https://sbhsciences.com/biosimilars)
          - [CELL & GENE THERAPY](https://sbhsciences.com/cgt)
          - [SMALL MOLECULE](https://sbhsciences.com/small-molecule)
    - [FTE MODEL](https://sbhsciences.com/fte-model)
    - [CONSULTING](https://sbhsciences.com/mentoring)
- Open submenu for INDICATIONS 
  
    - [NEUROLOGY](https://sbhsciences.com/neurology)
    - [METABOLIC](https://sbhsciences.com/metabolic)
    - [ONCOLOGY](https://sbhsciences.com/oncology)
    - [KIDNEY](https://sbhsciences.com/kidney)
    - [MUSCLE](https://sbhsciences.com/muscle)
- Open submenu for PRODUCTS 
  
    - [CYTOKINES](https://sbhsciences.com/cytokines)
    - [MONOCLONAL ANTIBODIES](https://sbhsciences.com/monoclonal-antibodies)
    - [GLYCOBIOLOGY](https://sbhsciences.com/glycobiology)
- Open submenu for INSIGHTS 
  
    - [NEWS AND BLOG](https://sbhsciences.com/sbh-blog-and-news)
    - [REFERENCES AND PUBLICATIONS](https://sbhsciences.com/references)
    - [STRATEGIC PARTNERSHIPS](https://sbhsciences.com/partnerships)

- Open submenu for ABOUT US 
  
    - [ABOUT SBH](https://sbhsciences.com/about-sbh)
    - [LEADERSHIP](https://sbhsciences.com/sbh-leadership)
    - [CONTACT](https://sbhsciences.com/contact)
    - [CAREERS](https://sbhsciences.com/careers)
- [SBH BIOVENTURE](https://sbhsciences.com/sbh-bioventure)
- [SOLUTIONS](https://sbhsciences.com/services)
  
   Show submenu for SOLUTIONS 
  
    - [CELL BASED ASSAYS](https://sbhsciences.com/cell-based-assay-services)
    - Open submenu for PRODUCT SERVICES 
      
          - [PROTEINS](https://sbhsciences.com/protein-production-services)
          - [MOLECULAR BIOLOGY](https://sbhsciences.com/molecular-biology-services)
          - [CELL CULTURE](https://sbhsciences.com/cell-culture-services)
          - [ORGANOIDS](https://sbhsciences.com/blog/organoids-mini-organs-grown-for-research-and-drug-development)
          - [EXOSOMES](https://sbhsciences.com/exosome-services)
    - [BIOMARKER TESTING](https://sbhsciences.com/biomarker-testing)
    - Open submenu for DRUG DISCOVERY 
      
          - [ADCC](https://sbhsciences.com/antibody-development-1)
          - [ELISA](https://sbhsciences.com/elisa-assays)
          - [BIOANALYTICAL](https://sbhsciences.com/bioanalytical-discovery-services)
          - [BIOSIMILARS](https://sbhsciences.com/biosimilars)
          - [CELL & GENE THERAPY](https://sbhsciences.com/cgt)
          - [SMALL MOLECULE](https://sbhsciences.com/small-molecule)
    - [FTE MODEL](https://sbhsciences.com/fte-model)
    - [CONSULTING](https://sbhsciences.com/mentoring)
- Open submenu for INDICATIONS 
  
    - [NEUROLOGY](https://sbhsciences.com/neurology)
    - [METABOLIC](https://sbhsciences.com/metabolic)
    - [ONCOLOGY](https://sbhsciences.com/oncology)
    - [KIDNEY](https://sbhsciences.com/kidney)
    - [MUSCLE](https://sbhsciences.com/muscle)
- Open submenu for PRODUCTS 
  
    - [CYTOKINES](https://sbhsciences.com/cytokines)
    - [MONOCLONAL ANTIBODIES](https://sbhsciences.com/monoclonal-antibodies)
    - [GLYCOBIOLOGY](https://sbhsciences.com/glycobiology)
- Open submenu for INSIGHTS 
  
    - [NEWS AND BLOG](https://sbhsciences.com/sbh-blog-and-news)
    - [REFERENCES AND PUBLICATIONS](https://sbhsciences.com/references)
    - [STRATEGIC PARTNERSHIPS](https://sbhsciences.com/partnerships)

Search

Search

Search

Search

![Human IL-4 Receptor Alpha (Soluble) Recombinant Protein](https://sbhsciences.com/hubfs/ChatGPT%20Image%20Jan%2020%2c%202026%2c%2012_20_59%20PM.png)

# *[cancer](https://sbhsciences.com/blog/tag/cancer) | [neurological](https://sbhsciences.com/blog/tag/neurological) | [immune/inflammation](https://sbhsciences.com/blog/tag/immune-inflammation) | [cardiovascular](https://sbhsciences.com/blog/tag/cardiovascular) | [infection](https://sbhsciences.com/blog/tag/infection)* Human IL-4 Receptor Alpha (Soluble) Recombinant Protein

Catalog #002-SIL6R

 

 

Description

 

Human IL-4 exerts its biological effects via signaling through its receptor system, IL-4R. There are two types of the IL-4 receptor complexes, the type I receptor consisting of the IL-4R alpha and the common gamma chain, and the type II receptor consisting of IL-4R alpha and the IL-13R alpha. The IL-4R alpha chain contains an extracellular domain of 207 amino acids, a transmembrane domain of 24 amino acids, and an intracellular domain of 569 amino acids. The secreted extracellular domain, sIL-4R alpha, also called CD124 is capable of blocking IL-4 activities. This receptor plays a major role in the regulation of the differentiation of naive CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4R alpha is a 23.7 kDa protein containing 207 amino acid residues consisting of only the extracellular domain of the IL-4R alpha.

 

###### Product Specific Information

 

Reconstitution: We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0mg/ml. 

Storage: This solution can then be diluted into other aqueous buffers and stored at 4°C. for 1 week or -20°C. for future use.

For research Purposes Only. Not for use in diagnostic or therapeutic procedures. 

 

 

| PROPERTIES |  |
| --- | --- |
| Species | Human |
| Expression System | Human Embryonic Stem Cells, HEK-293 |
| Molecular Weight | 23.7 kDa |
| Full Length | 207 amino acids |
| Purity | ≥97% by SDS-PAGE and HPLC Analyses |
| Form | Lyophilized |
| Endotoxin | \<1 EU/µg |
| Activity | The ED50 as determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is \[5.0 ng/ml (in the presence of 0.5 ng/ml IL-4), corresponding to a specific activity of \] 2 x 10 exp5 units/mg |
| Storage | -20°C |

### Sign up for our newsletter!

**Discovery Research Products & Services**  
(508) 650-6218 | [Inquiries@SBHsciences.com](mailto:Inquiries@SBHsciences.com)  
The World's Leading Provider of Cytokine Cell-Based Assays

Recombinant Cytokines, Enzymes, Antibodies, Cell-Based Assay and Innovative Process Development Solutions

**[COMPANY](https://sbhsciences.com/about-sbh)**  
[About Us](https://sbhsciences.com/about-sbh)   
[SBH Leadership](https://sbhsciences.com/sbh-leadership)   
[Company Presentation](https://sbhsciences.com/hubfs/43587181/SBH_Presentation.pdf)  
[Strategic Partnerships](https://sbhsciences.com/partnerships)  
[References and Publications](https://sbhsciences.com/references)  
[News and Blog](https://sbhsciences.com/sbh-blog-and-news)

[Careers](https://sbhsciences.com/careers)  
[Request a Quote](https://sbhsciences.com/contact)  
[Contact Us](https://sbhsciences.com/contact)

**[SERVICES](https://sbhsciences.com/services)**  
[Automated Western Blot](https://sbhsciences.com/platform-technologies#wb)  
[Bioanalytical](https://sbhsciences.com/bioanalytical-discovery-services)  
[Biomarker Testing](https://sbhsciences.com/biomarker-testing)  
[Cell-Based Assay](https://sbhsciences.com/cell-based-assay-services)  
[Cell Culture Services](https://sbhsciences.com/cell-culture-services)  
[Cell & Gene Therapy (CGT)](https://sbhsciences.com/cgt)  
[Small Molecule](https://sbhsciences.com/small-molecule)  
[Biosimilars](https://sbhsciences.com/biosimilars)  
[Antibody Development](https://sbhsciences.com/antibody-development-1)  
[ELISA Services](https://sbhsciences.com/elisa-assays)  
[Molecular Biology](https://sbhsciences.com/molecular-biology-services)  
[Organoids](https://sbhsciences.com/blog/organoids-mini-organs-grown-for-research-and-drug-development)  
[Exosomes](https://sbhsciences.com/exosome-services)  
[Protein Purification/Production](https://sbhsciences.com/protein-production-services)  
[FTE Scientist Model](https://sbhsciences.com/fte-model)  
[Consulting](https://sbhsciences.com/mentoring)

**INDICATIONS**  
[Oncology](https://sbhsciences.com/oncology)  
[Kidney](https://sbhsciences.com/kidney)  
[Muscle](https://sbhsciences.com/muscle)  
[Metabolic](https://sbhsciences.com/metabolic)  
[Neurology](https://sbhsciences.com/neurology)

**[PRODUCTS](https://sbhsciences.com/products)**  
[Request a Quote](https://sbhsciences.com/contact)  
[Cytokines](https://sbhsciences.com/cytokines)  
[Monoclonal Antibodies](https://sbhsciences.com/monoclonal-antibodies)  
[Glycobiology](https://sbhsciences.com/glycobiology)

**[SBH Bioventure](https://sbhsciences.com/sbh-bioventure)**

[**SBH Diagnostics**](https://sbhdiagnostics.com/#)

 

[![linkedin](https://sbhsciences.com/hs-fs/hubfs/Imported%20sitepage%20images/linkedin.gif?width=45&height=44&name=linkedin.gif)](https://www.linkedin.com/company/sbh-sciences)

 

 

©2026 SBH Sciences. All rights reserved. [Terms of Use](https://sbhsciences.com/tou) | [Privacy Policy](https://sbhsciences.com/tou#pp)

```json
{
  "@context" : "https://schema.org",
  "@type" : "BlogPosting",
  "author" : {
    "@type" : "Person",
    "name" : "Cytokines",
    "url" : "https://sbhsciences.com/blog/author/cytokines"
  },
  "dateModified" : "2026-01-20T20:41:27.046Z",
  "datePublished" : "2026-01-20T17:26:31.000Z",
  "headline" : "Human IL-4 Receptor Alpha (Soluble) Recombinant Protein",
  "mainEntityOfPage" : {
    "@id" : "https://sbhsciences.com/blog/human-il-4-receptor-alpha-soluble-recombinant-protein",
    "@type" : "WebPage"
  },
  "publisher" : {
    "@type" : "Organization",
    "logo" : {
      "@type" : "ImageObject",
      "url" : "https://sbhsciences.com/hubfs/Imported%20sitepage%20images/sbhlogo.png"
    },
    "name" : "SBH Sciences"
  }
}
```

```json
{
  "@context" : "https://schema.org",
  "@id" : "https://sbhsciences.com/blog/author/cytokines#author",
  "@type" : "Person",
  "email" : null,
  "name" : "Cytokines",
  "sameAs" : [ ]
}
```

```json
{
  "@context" : "https://schema.org",
  "@id" : "https://sbhsciences.com/blog/human-il-4-receptor-alpha-soluble-recombinant-protein#blogposting",
  "@type" : "BlogPosting",
  "author" : {
    "@id" : "https://sbhsciences.com/blog/author/cytokines#author"
  },
  "commentCount" : 0,
  "dateModified" : "2024-10-01T12:0000+0000",
  "datePublished" : "2026-01-20T17:2631+0000",
  "headline" : "Human IL-4 Receptor Alpha (Soluble) Recombinant Protein",
  "inLanguage" : "en",
  "keywords" : [ "cancer", "neurological", "immune/inflammation", "cardiovascular", "infection" ],
  "mainEntityOfPage" : "https://sbhsciences.com/blog/human-il-4-receptor-alpha-soluble-recombinant-protein",
  "name" : "Human IL-4 Receptor Alpha (Soluble) Recombinant Protein",
  "publisher" : {
    "@id" : "https://www.yourdomain.com#organization"
  },
  "url" : "https://sbhsciences.com/blog/human-il-4-receptor-alpha-soluble-recombinant-protein",
  "wordCount" : 212
}
```